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An orange and blue sign reads "ELFERS-LYON Rexall DRUGS" against a partly cloudy sky, mounted above a shingled building.
Publichall (CC BY-SA 3.0)

There was a time before every pharmacy you saw had a CVS or a Walgreens logo. There was a time before everything was the same chain, no matter what corner of the country you found yourself in. 

There were once all kinds of drugstore chains out there, but some of them are all but a memory now. Feeling nostalgic? Here are 10 now-defunct pharmacy chains you may remember.

Revco

A group of people, some in animal costumes and one dressed as a doll, stand outside a Revco Discount Drug Center for a ribbon-cutting ceremony under a "Welcome to Revco" sign.
AxlCobainVedder/Reddit.com

Founded: 1956
Shuttered: 1997
Approximate Peak Locations: 2,500

Revco was an Ohio chain, though it spread beyond and into the Southeast. It went bankrupt in the ’80s and was later purchased by CVS for a casual $2.8 billion.

Rexall

A corner street view featuring a Rexall Drug store with an orange sign, a traffic light, and a fire hydrant. Several buildings and parked cars line the street in the background.
TigerPaw2154 (CC BY-SA 3.0)

Founded: 1903
Shuttered: 1985
Approximate Peak Locations: 12,000

Founded under the retailers’ cooperative United Drug Stores and headquartered in Boston, Rexall had drugstores all over the country. There was even a Rexall Train at one point during the Depression. In the ’70s, they went downhill and died one by one. There are a few privately franchised locations out there, but they’re essentially extinct.

Eckerd Pharmacy

A brick Eckerd store with a drive-thru pharmacy and food mart, featuring a large blue Eckerd sign on the building and cars parked in front, under a cloudy sky.
Quizchris/Reddit.com

Founded: 1898
Shuttered: 2007
Approximate Peak Locations: 2,800


In Florida, Texas, and other areas of the Southeast, Eckerd was everywhere. Rite Aid gobbled them up, just as it gobbled so many others up.

Thrifty & Pay Less

A faded green and white sidewalk sign reads "Thrifty Cut Rate Drug Stores" on cracked concrete in front of boarded-up storefronts.
r/LosAngeles/Reddit.com

Founded: 1929 & 1932
Shuttered: 1994
Approximate Peak Locations: 500 & 200

Thrifty was born in Los Angeles and grew to 500 stores before it merged with Payless ShoeSource and became the cleverly titled Thrifty PayLess company. Then, two years later, guess who nabbed them? Yup. Rite Aid.

You can still get Thrifty ice cream at Rite Aid, by the way. And you should, because it’s some of the best ice cream you can eat.

Long’s Drugs

The exterior of a Longs Drugs store with a large red sign and a “24 HOURS” logo above the entrance. Several people are entering and exiting the store, and a person is pushing a shopping cart in the foreground.
buccalbu/Reddit.com

Founded: 1938
Shuttered: 2008
Approximate Peak Locations: 500

Long’s dominated Hawaii and the West Coast, and while it became CVS on the mainland, it’s still Long’s in Hawaii.

Adams Drug Company

A brick storefront with signs reading “WELLNESS CENTER,” “ADAMS DRUGS” with a mortar and pestle icon, and “emily GIFTs.” Large windows and a metal awning are above the sidewalk and parking lot.
Greg L. / Yelp

Founded: 1932
Shuttered: 1986
Approximate Peak Locations: 500

Adams Drug, which was born in Rhode Island and became popular in New England, eventually became Brooks Pharmacy, and then, by 2007, big bad Rite Aid came knockin’.

Drug Emporium

A brightly lit Drug Emporium store at dusk with two parked cars in front, glowing red signage, and wet pavement reflecting the store lights.
yeahdef/Reddit.com

Founded: 1977
Shuttered: 2003
Approximate Peak Locations: 300

Drug Emporium had a significant presence in the Midwest, but by 2001, they were filing for bankruptcy. A few years later, almost every last one of ‘em was gone.

Fay’s Drug

A matchbook cover with “Fay’s Drugs” in bold yellow letters. Below, it says: “Prescriptions our main concern... Over 2,000,000 filled since 1958.”
eBay

Founded: 1958
Shuttered: 1997
Approximate Peak Locations: 270

Upstate New York was home to plenty of Fay’s Drug stores. In the mid-’90s, JCPenney bought them out and then turned them into either a CVS or a Rite Aid, depending on the region.

Perry Drug Stores

A store display at Perry Drug Store features festive holiday decorations, including wreaths, Santa figurines, holiday signs, snowmen, nutcrackers, gift boxes, and poinsettias arranged on shelves and hanging on the wall.
Perry Drug Store / Yelp

Founded: 1957
Shuttered: 1995
Approximate Peak Locations: 200

This was the biggest pharmacy chain in Michigan in the ’80s, but I’ll give you one guess as to who bought it in 1995. It rhymes with bite-bade.

Arbor Drug

A logo reading "Arbor Drugs" in blue text with decorative flourishes above and below, printed on a light brown background.
eBay

Founded: 1963
Shuttered: 1998
Approximate Peak Locations: 200

CVS spent $1.4 billion to acquire Arbor Drug, another major Michigan drugstore. When the big corporations swoop, they swoop hard.

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Meet the Writer

Wilder Shaw is a staff writer at Cheapism who has written for publications like The Washington Post, Thrillist, Time Out, and more, but you most likely recognize him as Trick-or-Treater No. 2 from a 1996 episode of “The Nanny”. Give him a shout on Bluesky and Instagram.